Tissue Engineering and Translational Medicine Laboratory

Location within campus:	Dental Clinic Cuautepec, Tenayuca-Chalmita Avenue S/N, Block 190, Lot 7, Cuautepec Barrio Bajo, Gustavo A. Madero Borough, Mexico City.
Phone:	53 69 75 74
Head of Laboratory:	Dr.Raúl Rosales Ibáñez Full Professor “A” rosales_ibanez@unam.mx dr.raul.rosales@gmail.com
Researchers affiliated to the laboratory:	M.C Arely González González Arely_Glezz@hotmail.com M.C Rosario Morales de la Luz rosariomorales_99@yahoo.com
Technicians affiliated to the laboratory:	MVZ. María Leticia Olga Flores Sánchez letyflores1107@gmail.com Biol. Tomás Ernesto Villamar Duque vidutoer@yahoo.com.mx Mr. Fernando Barrón Moreno fbarron@campus.iztacala.unam.mx DMD. Amairany Rodríguez Navarrete cd.anyrn@outlook.com
Research lines per researcher:	Dr. Raúl Rosales Ibáñez. 1.-Tissue Engineering in Regenerative Medicine and Dentistry. 2.-Preclinical Studies and Biocompatibility. 3.-Nanomaterials for Medical Applications. M.C. Arely González González. 1.-Signaling Pathways in Mesenchymal Stem Cell Differentiation. 2.-Cytotoxic and Genotoxic Assays of Biomaterials for Tissue Engineering in Medicine and Dentistry.

Primary culture of differentiated cells and mesenchymal stem cells from different adult tissue sources, culture maintenance, molecular study of signaling through PCR and Western Blot analysis of their differentiation into different lineages, and confirmation of phenotype using techniques such as flow cytometry, histological staining, fluorescence microscopy, and electron microscopy. Seeding and maintenance of cultures to evaluate the cytotoxicity and genotoxicity of biomaterials for in vitro and in vivo applications using absorbance techniques to study viability, cell adhesion, and proliferation. Additionally, the Laboratory offers quality control services through immunohistochemistry/immunofluorescence assays to determine their usefulness in medicine and dentistry. Furthermore, our research group has expertise in conducting preclinical studies with rats, rabbits, and pigs to evaluate the biocompatibility of biomaterials and drugs.

Martín-Del-Campo, M., Rosales-Ibañez, R., & Rojo, L. (2019). Biomaterials for Cleft Lip and Palate Regeneration. International journal of molecular sciences, 20(9), 2176. DOI:10.3390/ijms20092176

Aguilar-Perez, F. J., Vargas-Coronado, R., Cervantes-Uc, J. M., Cauich-Rodriguez, J. V., Rosales-Ibañez, R., Pavon-Palacio, J. J., … Rodriguez-Ortiz, J. A. (2018). Preparation and characterization of titanium—segmented polyurethane composites for bone tissue engineering. Journal of Biomaterials Applications, 33(1), 11–22. DOI:10.1177/0885328218772708

Oliver Urrutia C, Rosales-Ibáñez R, Dominguez García MV, Flores-Estrada J, Flores-Merino MV. Synthesis and assessment of poly(acrylic acid)/polyvinylpyrrolidone interpenetrating network as a matrix for oral mucosa cells. Journal of Biomaterials Applications. 2020 Feb;34(7):998-1008. DOI:10.1177/0885328219883482.

Sánchez-Pech, J. C., Rosales-Ibáñez, R., Cauich-Rodriguez, J. V., Carrillo-Escalante, H. J., Rodríguez-Navarrete, A., Avila-Ortega, A., & Hernández-Sánchez, F. (2020). Design, synthesis, characterization, and cytotoxicity of PCL/PLGA scaffolds through plasma treatment in the presence of pyrrole for possible use in urethral tissue engineering. Journal of Biomaterials Applications, 34(6), 840–850. DOI:10.1177/0885328219882638

Valadez-González A, Rosales-Ibáñez R, Rodríguez-Navarrete A, Villamar-Duque T.E, Cano-Brown J, Carrillo-Escalante H.J, Ortiz-Fernández A & Hernández-Sánchez F. (2020). Tailoring surface properties of carbon nanofibers via oxidation and its influence on dental pulp stem cell viability of PCL/CNF composites. Polymer Bulletin. DOI:10.1007/s00289-020-03127-1

Entry profile of potential thesis students:

Service-oriented spirit, ability to work in a team, passion for research, demonstrate humane treatment, and affinity for working with animals (rats, rabbits, and pigs).

Service Social Data:

Social Service in the Tissue Engineering Program in Translational Medicine and Dentistry. Culturing eukaryotic cells. Assisting in the execution of cytotoxic and genotoxic assays on biomaterials, performing dental and other organ extractions from animal models, assisting in surgeries on rats, rabbits, and pigs, disseminating the knowledge generated in the Tissue Engineering and Translational Medicine Laboratory at national and international events.