| Location within campus: | Laboratory 17, Biomedicine Unit FES Iztacala |
| Phone: | 56231333 ext. 39842 |
| Head of Laboratory: | Dr. José Bustos Arriaga Full Career Professor “A” jose.bustos@iztacala.unam.mx |
| Technicians affiliated to the laboratory: | Q.F.B. Tannya Karen Castro Jiménez tannya.castro@iztacala.unam.mx |
| Research lines per researcher: | Variability in mechanisms of evasion of the immune response and the viral genome metabolism of arboviruses |
Isolation of circulating arboviruses in Mexico and the characterization of the mechanisms involved in their adaptability capacity.
Bustos-Arriaga, J., Gromowski, G. D., Tsetsarkin, K. A., Firestone, C.-Y., Castro-Jiménez, T., Pletnev, A. G., … Whitehead, S. S. (2018). Decreased accumulation of subgenomic RNA in human cells infected with vaccine candidate DEN4Δ30 increases viral susceptibility to type I interferon. Vaccine, 36(24). https://doi.org/10.1016/j.vaccine.2018.04.087
Bustos-Arriaga, José, Mita-Mendoza, N. K., Lopez-Gonzalez, M., García-Cordero, J., Juárez-Delgado, F. J., Gromowski, G. D., … Cedillo-Barrón, L. (2016). Soluble mediators produced by the crosstalk between microvascular endothelial cells and dengue-infected primary dermal fibroblasts inhibit dengue virus replication and increase leukocyte transmigration. Immunologic Research, 64(2), 392–403. https://doi.org/10.1007/s12026-015-8675-8
Katzelnick, L. C., Fonville, J. M., Gromowski, G. D., Arriaga, J. B., Green, A., James, S. L., … Smith, D. J. (2015). Dengue viruses cluster antigenically but not as discrete serotypes. Science. https://doi.org/10.1126/science.aac5017
Tsetsarkin, K. A., Liu, G., Kenney, H., Bustos-Arriaga, J., Hanson, C. T., Whitehead, S. S., & Pletnev, A. G. (2015). Dual miRNA Targeting Restricts Host Range and Attenuates Neurovirulence of Flaviviruses. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1004852
Gromowski, G. D., Firestone, C.-Y., Bustos-Arriaga, J., & Whitehead, S. S. (2015). Genetic and phenotypic properties of vero cell-adapted japanese encephalitis virus SA14-14-2 vaccine strain variants and a recombinant clone, which demonstrates attenuation and immunogenicity in mice. American Journal of Tropical Medicine and Hygiene, 92(1). https://doi.org/10.4269/ajtmh.14-0427
| Entry profile of potential thesis students: | Graduates from chemical and biological science fields with an interest in virology and pathogen-host interaction mechanisms. |
| Service Social Data: | Molecular Biology and Immunology of Medically Important Arboviruses Circulating in Mexico (2020-12/63-885). Activities to be carried out include the handling of cell cultures, serological techniques for viral antigen detection, and molecular biology applied to the study of viral replication. |