| Location within campus: | UIICSE First Floor |
| Phone: | 55 56231333 ext. 39805 |
| Head of Laboratory: | Dr. María Rosa Avila Costa Full Professor B nigraizo@unam.mx |
| Researchers affiliated to the laboratory: | Dr. José Luis Ordoñez Librado jlordonez@comunidad.unam.mx Mr. Enrique Montiel Flores emonflo@yahoo.com.mx |
| Technicians affiliated to the laboratory: | Patricia Aley Medina ytap_1@hotmail.com Jesús Espinosa Villanueva cxmtz3@hotmail.com |
| Research lines per researcher: | Biochemical, Behavioral, and Morphological Aspects of Three Experimental Models of Parkinson’s and Alzheimer’s Disease. |
The Neuromorphology Laboratory primarily focuses on cellular and molecular biology aspects. We have a transmission/scanning electron microscope, fluorescence microscopes, and light microscopes. We conduct behavioral tests and determine lipid peroxidation. Recently, we established a novel experimental model for the study of Parkinson’s disease, where the alterations are progressive and bilateral. Additionally, we are currently establishing an Alzheimer’s model.
Subramaniam Ganesh, Antonio V. Delgado-Escueta, Toshiro Sakamoto, Maria Rosa Avila, Jesus Machado-Salas, Yoshinobu Hoshii, TakumiAkagi, Hiroshi Gomi, Toshimitsu Suzuki, Kenji Amano, Kishan Lal Agaewala, Yuki Hasegawa, Dong-Sheng Bai, Tokuhiro Ishihara, Tsutomu Hashikawa, Shigeyoshi Itohara, Eain M. Cornford, Hiroaki Niki and Kasuhiro Yamakawa. Targeted disruption of the Epm2a gene causes formation of Lafora inclusions bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice. Human Molecular Genetics 12 (11): 1-12 2002. ISSN: 0964-6906
María Rosa Avila-Costa, Laura Colín-Barenque, Teresa I. Fortoul, Jesús P. Machado-Salas, Jesús Espinosa-Villanueva, Concepción Rugerio-Vargas and Selva Rivas-Arancibia. Memory Deterioration In An Oxidative Stress Model And Its Correlation With Cytological Changes On Rat Hippocampus Ca1. Neuroscience Letters 270 Pp. 107-109 1999. ISSN: 0304-3940
Ordoñez-Librado JL, Gutierrez-Valdez AL, Colín-Barenque L, Anaya-Martínez V, Díaz-Bech P, Avila-Costa MR. Inhalation of divalent and trivalent manganese mixture induces a Parkinson’s disease model: immunocytochemical and behavioral evidences. Neuroscience. 2008 Jul 31;155(1):7-16. ISSN: 0306-4522
Ordoñez-Librado JL, Anaya-Martínez V, Gutierrez-Valdez AL, Colin-Barenque L, Montiel-Flores E, Avila-Costa MR. Manganese inhalation as a Parkinson disease model. Parkinson’s Disease, Special Issue Animal Models of Parkinson’s Disease (AMPD). Parkinson Disease, (2011) Vol 2011: 1-14, Article ID 612989. ISSN : 2042-0080
| Entry profile of potential thesis students: | To be a 7th-semester student in Biology or Psychology programs; for postgraduate students coming from programs in Biological Sciences, Neurobiology, or Biomedical Sciences. |
| Service Social Data: | Key: 2020-12/63-7 ESTABLISHING MORPHOLOGICAL, BIOCHEMICAL, AND BEHAVIORAL DIFFERENCES IN TWO EXPERIMENTAL MODELS OF PARKINSON’S DISEASE TO DETERMINE THE IDEAL MODEL FOR DISEASE STUDY AND ADAPT PHARMACOLOGICAL TREATMENTS. |